This website uses cookies. By continuing you are agreeing to our privacy policy.

Monica Goldklang, MD

Research Awards Nationwide Recipient (2015-2016)

Columbia University Medical Center
How Does Cigarette Smoke Lead to Lung Damage in Emphysema?
Biomedical Research Grant
Funded by the American Lung Association of the Northeast

Although we know that cigarette smoke is the primary cause of COPD, the way in which cigarette smoke exposure leads to lung damage is still not fully understood. Smoking has recently been identified to alter ion channel function essential for normal cellular responses to injury. We plan to study the role of the BK channel in lung destruction. Mice bred with mutant BK channels have reduced lung destruction when exposed to smoke despite developing airway inflammation. Understanding the role for BK channel function in lung injury may provide potential novel treatment approaches for patients with COPD.

Update: In the Year 1, we have performed experiments to better understand the regulation of BK channels in various models of lung injury. We have examined the role of certain enzymes in immune cells called macrophages in mice bred with mutant BK channels. Through this research, we are gaining a greater understanding of the role of BK channels in emphysema development.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.