This website uses cookies. By continuing you are agreeing to our privacy policy.

Joshua Mezrich, MD

Research Awards Nationwide Recipient (2013-2015)

University of Wisconsin, Madison, WI
Preventing Environmentally Triggered Asthma Flareups
Biomedical Research Grant
Funded in Partnership with the American Lung Association of the Upper Midwest

Research has shown that polycyclic aromatic hydrocarbons (PAH) may be responsible for aggravating asthma through the activation of the of the aryl hydrocarbon receptor (AHR). This activation leads to the generation of a pathogenic population of T cells that generates IL-17, which in turn, worsen airway inflammation in some models. Dr. Mezrich and his team believe that this represents a new, very specific mechanism for airway inflammation in response to pollution. Their goal is to prove this mechanism is dependent on the AHR in T cells in murine models of airway inflammation, to identify whether PAHs are causing this effect, and also show that they can block or at least reduce this inflammatory response by modulating the response of the AHR on these T cells.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.