Eric Collisson, MD
Research Awards Nationwide Recipient (2015-2016)
University of California, San Francisco
Funding in Partnership with the American Lung Association of the Upper Midwest
Using Genomics to Attack Lung Cancer
While we are gaining insight into the workings of the lung cancer cell by the use of genome sequencing, our efforts at personalizing treatments currently only help about one in five patients. We will use new therapies being developed to attack lung cancer, using mutant cancer genes against the tumor's own growth. We will examine how a gene complex responsible for managing the way other genes are packaged affects the transformation of normal lung cells to cancer cells. We will also look at how mutations in a specific gene affect the formation and the progression of lung cancer.
Update: We have been studying a class of genes called the SWI/SNF genes in lung cancer. Our experiments have shown that mutations in these genes are likely early events in the establishment and evolution of cancer. We now think the genes may be involved in both early initiation of the cancer and its later growth and are trying to learn more about the liabilities cancer cells harboring these mutations have, and how we might capitalize on them.