Daniel Greif, MD
Research Awards Nationwide Recipient (2014-2016)
Yale University, New Haven, CT
Funded by the American Lung Association of the Northeast
Smooth Muscle's Role in Pulmonary Hypertension
Pulmonary hypertension (PH) is a devastating disease with elevated blood pressure in the blood vessels of the lung. In PH, there is increased smooth muscle in blood vessels, which raises blood pressure. Current treatments, which are of limited benefit, aim to decrease blood pressure by widening blood vessels. None of these treatments directly alter the accumulation of excessive smooth muscle, because the pathways governing smooth muscle accumulation are not well understood. We will use mouse models of human PH to identify key steps that contribute to excess smooth muscle, which could suggest new treatment approaches.