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Clinical Trials

Trial of Roflumilast in Asthma Management (TRIM)




Multi-Center Trial


The American Lung Association Airways Clinical Research Center (ACRC) network is evaluating measurements of asthma symptoms and its impact on quality of life for people with who have a BMI of 30 or more. This population tends to have poor asthma control that does not respond well to usual asthma treatments.


May 1, 2017 - April 30, 2020



The Trial of Roflumilast in Asthma Management (TRIM) is testing to see whether roflumilast is safe and tolerable to use for asthma control. TRIM is a 6-month study with seven clinic visits involving breathing tests, questionnaires, and two blood draws. Participants will also be asked to fill out daily asthma diary cards.

Men and women age 18 or older with poorly controlled asthma and an elevated BMI are eligible to enroll in TRIM at five ALA ACRC clinical centers: Duke Asthma Allergy Airway Center (North Carolina), Icahn School of Medicine, Mount Sinai National Jewish Health Respiratory Institute (New York), Northwestern Airways Disease Center (Illinois), Airways Disease Center the University of Arizona (Arizona), and the Vermont Lung Center (Vermont).

If you would like to participate in this trial, please contact one of the participating centers.

See recruiting centers below and contact the one nearest you


University of Arizona Asthma and Airway Disease Research Center
1501 N. Campbell Avenue, PO Box 245030, Rm 2351B
Tucson, Arizona 85724
Contact: Chelsey Large, Research Coordinator
(520) 626-5590
[email protected]


Northwestern Airways Disease Center
676 North Saint Clair, 14th Floor
Chicago, IL 60611
Contact: Jenny Hixon, Senior Coordinator
[email protected]

New York

Icahn School of Medicine
Mount Sinai National Jewish Health Respiratory Institute
One Gustave L. Levy Place
Box 1118
New York, New York 10029
Contact: Chelsea Chung, Clinical Research Coordinator
(212) 241-8655
[email protected]

North Carolina

Duke Asthma Allergy Airway Center
1821 Hillandale Road
Suite 25A
Durham, North Carolina 27705
Contact: Catherine Foss, BS, RRT, RPFT, CCRC, Lead Coordinator
(919) 479-0861
[email protected]


Vermont Lung Center
792 College Parkway, Suite 305
Colchester, VT 05446
Contact: Kevin Hodgdon, Coordinator
(802) 847-8602
[email protected]

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