EGFR stands for epithelial growth factor receptor, a protein that is present on the surface of both normal cells and cancer cells such as lung cancer cells. A mutation of this protein causes cancer.
An ALK mutation is a rearrangement in a gene called anaplastic lymphoma kinase. This gene rearrangement mutation joins another gene to ALK, telling cancer cells to multiply.
ROS-1 is an enzyme that is coded by the ROS-1 gene. A mutation leads to a rearrangement of the gene, which causes the cancer to grow.
BRAF V600E is a specific mutation in the BRAF gene. It makes a protein that helps drive cancer growth.
PD-L1 is a protein expressed by cancer cells that keep the immune system from attacking the cancer. The PD-L1 levels in your tumor may help predict whether or not immunotherapy is right for you.
I Don't Know:
Ask your doctor about comprehensive genomic testing. This testing looks for a large number of mutations and proteins in the genes known to be associated with lung cancer.