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Indiana Researcher Joins American Lung Association Research Team

Lung Association expands research investment to $8.7 million, making headway on its commitment to double its investment in research

(November 20, 2019) - INDIANAPOLIS

For more information please contact:

Jill Thompson
[email protected]

Today, the American Lung Association announced its new research team, which includes Andrea Frump, Ph.D., from Indiana University. This year, the organization has also increased its research investment to $8.7 million, through awards for both our Airways Clinical Research Center (ACRC) Network and its innovative Awards & Grants program. This announcement comes at an important time, as November is both Lung Cancer Awareness Month and Chronic Obstructive Pulmonary Disease (COPD) Awareness Month. 

The Awards and Grants Program provides investigators with the funds, at all levels of their career, to conduct novel and promising research to prevent, treat and even cure lung cancer and lung disease. The ACRC is the nation's largest not-for-profit network of clinical research centers dedicated to asthma and COPD treatment research that promises to have a direct, positive impact on patient care. 

Research projects funded by the Lung Association are carefully selected through rigorous scientific review and represent the investigation of a wide range of complex issues to help combat and reduce the suffering and burden of lung disease. 

Dr. Frump was given the Calatlyst Award for her project, titled “Identification of the Apelin-Mediated Transcriptome During Pulmonary Hypertension-Induced Right Ventricular Failure.

Pulmonary hypertension (PH) is a disease characterized by narrowing of the blood vessels of the lung; leading to high blood pressure in the lungs, right heart failure and death. Survival is determined by right heart function. Patients with poor right heart function are more likely to succumb to disease and patients with preserved right heart function are more likely to survive. Dr. Frump’s study addresses how the protective factor apelin regulates the right heart, and whether apelin-mediated signaling could be developed as a new therapy. Specifically, she wants to identify how apelin regulates cells in the heart and if inhibiting apelin worsens heart function. Once they complete their studies, they will have identified what changes as the heart fails and established new ways apelin stops right heart failure. Dr. Frump’s studies will lead to the development of new therapies for PH patients.

See project overviews of all funded projects at


About the American Lung Association

The American Lung Association is the leading organization working to save lives by improving lung health and preventing lung disease, through research, education and advocacy. The work of the American Lung Association is focused on four strategic imperatives: to defeat lung cancer; to improve the air we breathe; to reduce the burden of lung disease on individuals and their families; and to eliminate tobacco use and tobacco-related diseases. For more information about the American Lung Association, a holder of the coveted 4-star rating from Charity Navigator and a Gold-Level GuideStar Member, or to support the work it does, call 1-800-LUNGUSA (1-800-586-4872) or visit:

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