Soo Jung Cho, M.D.
Joan & Sanford I. Weill Medical College of Cornell University
Funded by the American Lung Association of the Northeast
Why Are Older People More Susceptible to Fibrotic Lung Disease?
Idiopathic pulmonary fibrosis (IPF) is a rapidly progressive, fatal lung disease that is more prevalent in the aging population. Glycolysis—the breakdown of glucose by enzymes—plays an important role in fibrosis, a lung injury caused by the development of fibrous connective tissue. A protein called glucose transporter 1 (GLUT1), the major glucose transporter in the lung, may have an important role in regulating lung fibrosis. We will investigate the mechanism by which GLUT1 regulates fibrosis. Our findings may provide a potential explanation for why older people are more susceptible to fibrotic lung disease. Our ultimate goal is to develop therapies for IPF based on targeting GLUT1 and molecular mechanisms that regulate it.