Seyed Javad Moghaddam, M.D.
University of Texas M.D. Anderson Cancer Center
Funded by LUNG FORCE
Focusing on Gender Specific Cell-Signaling Pathways Involved in Lung Cancer Growth
Mutations of KRAS gene are the most common genetic alterations found in lung cancer. These mutations are heavily associated with tobacco exposure, and poor prognosis. Unfortunately, our knowledge of the molecular mechanisms affecting KRAS-induced lung cancer growth is deficient. Moreover, attempts at targeting KRAS mutant lung tumors with drugs have thus far failed, clearly indicating that alternative strategies are needed. Our goals are to understand gender- and cell-specific signaling pathways that are involved in KRAS mutant lung cancer growth, and to target these pathways and ultimately develop personalized therapies for this fatal subtype of lung cancer.