Seyed Babak Mahjour, M.D., Ph.D.
Joan & Sanford I. Weill Medical College of Cornell University
Funded by the American Lung Association of the Northeast
Developing Small Airway Models to Better Comprehend COPD
Chronic obstructive pulmonary disease (COPD) is characterized by progressive irreversible narrowing of small airways due to smoking or other environmental stressors. No effective therapies are currently available, largely due to limited knowledge about COPD's mechanisms and the absence of adequate study models. We will develop novel, "personalized" models of small airway pathology in COPD, in which different cell types normally present in the small airways and altered by the disease will be isolated and integrated into an experimental system. This system will reconstruct interactions between the cells which may underlie disease development. These studies will lead to identification of novel disease mechanisms that can be targeted in the future to more effectively treat COPD.