Robert Guzy, M.D., Ph.D.
University of Chicago
Funded by the American Lung Association of the Upper Midwest
Growth Factor May Be Helpful in Treating Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) causes progressive scarring of the lungs, severe breathlessness, and too little oxygen. The cause of IPF is unknown. Despite current FDA-approved antifibrotic therapies, overall survival is just 3-5 years after diagnosis. Substances called Fibroblast Growth Factors (FGFs) have been implicated in pulmonary fibrosis, but their exact contribution is unclear. Our initial research suggests that FGF2 administration may decrease pulmonary fibrosis severity. We plan to define the mechanism by which FGF2 decreases pulmonary fibrosis, and determine its potential for therapeutic use.