Lokesh Sharma, Ph.D. | American Lung Association

This website uses cookies. By continuing you are agreeing to our privacy policy.

Lokesh Sharma, Ph.D.

Yale University
Funded by the American Lung Association of the Northeast
Gene Deficiency Linked to Increased Pneumonia Survival

Klebsiella pneumoniae is a germ that causes pneumonia, with a mortality that can reach up to 70 percent when infection spreads to other organs. Current, antibiotic treatment often fails due to development of antibiotic resistance, so there is an urgent need for new therapies. We have found a deficiency in a gene called Chit1, present in up to 20 percent of humans, gives mice a significant advantage during pneumonia. Absence of this gene helps mice limit bacterial spread to other organs and increase survival with or without antibiotic use. Understanding the mechanisms of the advantage provided by Chit1 deficiency will help to develop new therapies that can boost the host defense against bacterial infection to reduce mortality.

Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.


LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.