Hong Ji, Ph.D.
Cincinnati Children's Hospital Medical Center - Research Foundation
Funded in partnership with the AAAAI Foundation
Seeking Personalized Treatment for Severe Asthma in Children
Asthma remains the leading cause of emergency care and hospitalization in children. Standard asthma treatments including bronchodilators and corticosteroids and are not completely effective in all asthmatics, especially in those with severe/difficult-to-treat asthma. There remains a great need for alternative personalized asthma therapy. We will address this unmet need by identifying biological mechanisms that switch genes on and off for difficult-to-treat childhood asthma and investigate how they contribute to the diversity of patients' disease and response to treatment. Once completed, this research will facilitate better identification of difficult-to-treat asthma and may provide novel therapeutic targets for personalized asthma therapies.