Henning Willers, MD | American Lung Association

Location Select your location

Henning Willers, MD

Massachusetts General Hospital
Funded in partnership with the American Lung Association of the Northeast and the American Thoracic Society
Attacking Lung Cancer Before It Develops Drug Resistance

Targeted drugs like erlotinib commonly shrink lung cancers that depend on mutated EGFR (EGFRmut). However, invariably cancer cells survive, become drug resistant and cause tumor regrowth. In this study, we propose attacking the tumor before drug resistance and recurrence occur. We will take advantage of a unique clinical trial that allows us to biopsy EGFRmut tumors before drug resistance develops. Coupled with laboratory studies we will find out how tumor cells manage to survive the targeted therapy and how we can disrupt this ability. Our research may lead to a dramatic change in how we treat EGFRmut cancers, thereby prolonging lives and perhaps even achieving cures in some patients.

Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.


LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.