Deborah Winter, Ph.D. | American Lung Association

Deborah Winter, Ph.D.

Northwestern University
Funded by the American Lung Association of the Upper Midwest
Using Cells from Lung Transplants to Better Understand Pulmonary Fibrosis

Pulmonary fibrosis , or scarring of the lungs, is a leading cause of death in people with the autoimmune disorder systemic sclerosis (SSc). Current treatments are only marginally effective. Recent work has suggested that immune cells in the lung called macrophages play a key role in the development of pulmonary fibrosis in SSc patients. We will compare the network of genes expressed in macrophages from the healthy lungs of donors to the fibrotic (scarred) lungs of transplant recipients. We will also examine the variability in these macrophage gene networks among these patients. Identifying the molecular regulators and environmental signals that reprogram lung macrophages will offer a better understanding of pulmonary fibrosis and will likely lead to specific targets for therapy.

Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.


LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.