Timothy Burns, MD, PhD
Research Awards Nationwide Recipient (2014-2016)
University of Pittsburgh, Pittsburgh, PA
Funded in Partnership with the American Lung Association of the Upper Midwest
Determining How Two Genes Interact in Lung Cancer
Recent advances in the treatment of lung cancer have confirmed that the disease is not a single disease entity but rather a collection of distinct cancers driven by cancer genes called oncogenes which cause the tumors to grow. This knowledge has led to the development of targeted therapies for a percentage of patients. One im-portant oncogene, c-MET, is required for a tumor to grow while another gene, TWIST 1, has been shown to regulate the c-MET gene. This study will determine how these two genes interact and how drugs may modulate their activity.