Guofei Zhou, PhD
Research Awards Nationwide Recipient (2013-2015)
University of Illinois, Chicago, IL
Funded in Partnership with the American Lung Association of the Upper Midwest
Role of Tumor Suppressor Protein in Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating disease associated with progressive and irreversible destruction of the lung architecture. The cause of IPF remains largely unknown even as the annual incidence of IPF is rising. It has been suggested that patients with IPF express increased levels of a certain tumor suppressor protein [VHL] in centers of scarring. This research will attempt to address the regulation of VHL and the causal role of VHL in pulmonary fibrosis.