Elnaz Atabakhsh, PhD | American Lung Association

Elnaz Atabakhsh, PhD

Research Awards Nationwide Recipient (2014-2016)

Massachusetts General Hospital, Boston, MA
Gene Mutation Makes Lung Cancer Less Responsive to Treatment

We are studying the function of a protein called KDM4A in non-small cell lung cancer (NSCLC). KDM4A helps regulate how genes are organized. We found when KDM4A is over-produced in cells there are specific alterations to the organism's DNA. These alterations result in selection of regions involved in cancer drug resistance. We have also identified a KDM4A gene variant that is associated with poor outcome in NSCLC patients. This variant also changes lung cancer cell sensitivity to certain drug treatments. We will study the impact of the genetic alterations caused by KDM4A overexpression and establish how KDM4A levels impact lung cancer cells' response to chemotherapy. Our research could identify new treatment options for NSCLC patients.

Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

What is LUNG FORCE?

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.