Beata Kosmider, PhD
Research Awards Nationwide Recipient (2014-2016)
National Jewish Health, Denver, CO
How Does Smoke Impair A Protein That Protects Against Lung Injury?
Cigarette smoke is the most common cause of emphysema but the way in which it causes emphysema is still not fully understood. Research has suggested that a protein called CRIF-1 protects the lung's air sacs, known as alveoli, from injury caused by cigarette smoke. However, this protection seems to wane as emphysema progresses. We will determine the way in which chronic cigarette smoke impairs CRIF-1 as emphysema progresses by investigating injuries to the alveoli in patients with mild, moderate and severe emphysema. Our study will lead to much needed treatments to slow emphysema's development.