Bartosz Szczesny, PhD | American Lung Association

Location Select your location

Bartosz Szczesny, PhD

Research Awards Nationwide Recipient (2015-2016)

University of Texas Medical Branch at Galveston
Damage to Mitochondrial DNA May Trigger Inflammation in Airway Cells

Airway inflammation is the initial event in the development of several lung diseases. Although the connection between inhaled environmental pollutants and inflammatory lung disease is well established, we still do not fully understand what happens at the molecular level. We will study the role of mitochondrial DNA in inflammatory lung disease. Mitochondria are structures within cells that convert the energy from food into a form that cells can use. They have a small amount of their own DNA. We will study whether damage to mitochondrial DNA triggers the inflammatory response in airway epithelial cells. The findings may lead to new ways to prevent or treat inflammatory lung diseases.

Update: In Year 1 of the project, we made significant progress in the study of how damage to mitochondrial DNA triggers the inflammatory response in airway epithelial cells. We established a comprehensive picture of several critical mitochondrial and cellular functions in response to various levels of mitochondrial DNA damage.

Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

What is LUNG FORCE?

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.