Anurag Singh, PhD
Research Awards Nationwide Recipient (2013-2015)
Boston University, Boston, MA
Understanding Role of Mutated KRAS Gene in Lung Cancer
Lung cancers frequently have altered [mutated] genes. Of these, the mutated KRAS gene is now viewed as a central linchpin in driving cancer progression; this mutation is found in 20-30% of lung cancer cases. Dr. Singh and team aims to identify molecules that are regulated by mutant KRAS, cause changes in cancer cell appearance and behavior in mouse tumor models, or may affect how tumors respond to anti-cancer chemotherapeutic agents.