Alexei Tumanov, MD, PhD
Research Awards Nationwide Recipient (2014-2016)
Trudeau Institute, Saranac Lake, NY
Funded in partnership with the American Lung Association of the Northeast
Regulating Immune System's Excessive Response to Influenza in Lungs
Lung damage induced by influenza infection is a significant cause of death worldwide. Much of this lung damage results from an excessive immune-system response mounted by the body in an attempt to clear the virus. We want to find out how to block the aspects of the immune response that cause harm to the lungs without sacrificing those that provide protection. We will study the ability of a specific immune-system regulator called lymphotoxin-beta receptor to inhibit influenza-associated harm without limiting protective immune responses. Our research will lead to new strategies for treating influenza and other respiratory diseases.