Amanda Poholek, Ph.D. | American Lung Association

This website uses cookies. By continuing you are agreeing to our privacy policy.

Amanda Poholek, Ph.D.

University of Pittsburgh
Protein Holds Clue to Allergic Airway Inflammation

Allergic asthma is a chronic lung disease that occurs in response to allergens in the environment. Asthma is driven in part by inappropriate activation of T cells, an important component of the immune system. Transcription factors are proteins that alter T cell function to become inflammatory and drive disease. In an animal model of asthma, we found the presence of the transcription factor Blimp-1 in T cells drives allergic airway inflammation. We will identify the environmental factors that lead to the activation of Blimp-1 and investigate how Blimp-1 causes T cells to drive allergic asthma. We expect these studies to identify potential drug targets for specific therapies that would treat the causes of asthma, rather than symptoms.

Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.


LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.