Studies Currently Underway

Study of Soy Isoflavones in Asthma (SOYA)
Co-Funded by the National Institutes of Health's National Heart, Lung and Blood Institute
This study will test the novel hypothesis that dietary supplementation with soy isoflavones is an effective treatment in patients with poorly controlled asthma. "The SOYA study, which is nearing completion, will provide important new information on the potential role of a novel treatment for asthma, one that is inexpensive and safe."
- SOYA Lead PI Lewis J. Smith, MD at Northwestern University.

Study of Asthma and Nasal Steroids (STAN)
Co-Funded by the National Institutes of Health's National Heart, Lung and Blood Institute
This study will determine if the treatment of chronic sinusitis and rhinitis with nasal steroids improves asthma control, lung function and quality of life in patients with poorly controlled asthma and chronic rhinitis/sinusitis. "This research is important because it will allow us to determine if treating sinonasal disease in patients with asthma also affects their asthma management."
- STAN Lead PI Anne E. Dixon, MD at University of Vermont.

Long-acting Beta Agonist Step-Down Study (LASST)
Co-funded by GlaxoSmithKline
The study will determine the optimal treatment strategy to taper well controlled asthmatics off of therapy. The ACRC will compare three approaches of patient care to see which results in the lowest rate of failure over 48 weeks of follow up. "One of the most common dilemmas currently faced by practicing physicians is how to reduce therapy once asthma is controlled on combination ICS/ LABA. A study evaluating outcomes of reducing treatment with long-term followup and using outcomes relevant to patients and clinicians is needed"
- LASST Lead PI Linda Rogers, MD at New York University

Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients with Asthma (CPAP)
Co-Funded by the National Institutes of Health's National Heart, Lung and Blood Institute
This study will test whether the use of CPAP, a current treatment for sleep apnea, will improve asthma control. "The CPAP trial is a prime example of translational research. This study will be a new way to treat asthma without medications."
- CPAP Lead PI Mike Busk, MD formerly of Indiana University.