Other Completed Trials

Major Findings | Other Completed Trials | Protocols Currently Recruiting 

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Patient recruitment for the following studies has been completed and data are under analysis. Results will be submitted for peer-review journal publication.

Are there genetic variants that predict how patients will respond to asthma medications? 
An ancillary study to the LOCCS Trial, the Pharmacogenetics of Asthma Monotherapy study looked to identify genetic variants that predicted which patients responded favorably to any of the drugs in the LOCCS trial and which patients experienced side effects. The results of this ancillary study may enable researchers to predict which patients will respond favorably to these various treatments. 

Is Methacholine Bronchoprovocation challenge still a sensitive test in the diagnosis or confirmation of asthma?
The network’s eighth study, Study of MethaCholine Bronchoprovocation Influence of high potency Inhaled corticoSteroids Core Study (MeClS) will evaluate whether methacholine challenge in subjects ages 12 to 70 with stable asthma is a sensitive test in the diagnosis or confirmation of asthma and whether the use of high potency inhaled corticosteroids alters methacholine responsiveness. Results will be presented at the 2010 American Thoracic Society Meeting on May 16.

Can Acid Reflux Treatment Help Children with Asthma?
The network’s seventh study, Study of Acid Reflux in Children with Asthma (SARCA) which is being funded by NIH’s National Heart, Lung and Blood Institute, will examine whether there is a connection between asthma and gastroesophageal reflux (GERD) and whether treatments for GERD will decrease asthma flare-ups in children. The protocol will be similar to the SARA protocol but will focus on children with asthma.